FAME1_SAMD12

Gene
SAMD12
Disease
FAME1
Inheritance
AD
Classification
Definitive
Total Score
12
Publications Reviewed
4
Publication Span
6.84 years
Last Updated
8/14/25
Curator(s)
Macayla Weiner, Laurel Hiatt

Note: Maximum score caps apply at evidence type, category, and supercategory levels, so section totals may be lower than the raw sum of row scores.

Genetic evidence

Total: 10

Singular EvidenceProbandsPMID:395698766
Collective EvidenceAllelePMID:395698762(TTTCA)exp counts were inversely correlated with the age at onset for cortical tremor and epilepsy
Collective EvidenceComputationalPMID:322032000.5
Collective EvidenceSegregationPMID:30194086 PMID:299392031.5
4 rows

Experimental evidence

Total: 2

FunctionBiochemical functionPMID:295074231RNA and transc reg
FunctionProtein interactionPMID:295074231decrease + mutant
2 rows